RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

In this episode we discuss: What microglia are and why they’re essential for maintaining healthy brain function How chronic inflammation can transform protective microglia into drivers of neurodegeneration The emerging science of immunometabolism and mitochondrial function Why insulin resistance, obesity, and type 2 diabetes dramatically increase dementia risk The limitations of the traditional amyloid hypothesis and what newer research suggests How lifestyle interventions have demonstrated measurable improvements in cognitive outcomes The powerful connection between the gut microbiome, systemic inflammation, and brain health Why sleep, exercise, and nutrition remain the most impactful tools for protecting the brain The truth about the APOE4 gene—and why genetics are not destiny Show notes: Brain Defenders by Dr. David Perlmutter Dr. Perlmutter’s website POINTER Study Ornish & Tanzi Alzheimer’s lifestyle intervention study RHR: How to Sharpen and Protect Your Mind for a Lifetime, with Dale Bredesen RHR: Prevention and Treatment of Alzheimer’s from a Functional Perspective—with Dr. Dale Bredesen Learn more about the Adapt Naturals Core Plus Bundle or take our quiz to see which p...